# Renal function Assignment | Professional Essay Writers

Renal function can be calculated different ways but the most common ways are using the Cockcroft-Gault and CKD-EPI equations (see below). If adjustments to dosing are required due to decreased renal function, it is important to know which equation should be used. This can be found in a drug reference or the package insert for a particular medication. In general, if renal cutoffs are expressed as mL/min the Cockcroft-Gault equation should be used but if renal cutoffs are expressed in mL/min/1.73m2 then the CKD-EPI equation should be used. Different equations are necessary to calculate renal function in the pediatric population.

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The Cockcroft-Gault equation is as follows:

• CrCl = [(140-age) (ideal body weight)]/[(72) (SCr)] x 0.85 (if female)
• age is expressed in years
• weight is expressed in kg [ideal body weight (IBW) should be used except for obese patients, in which case adjusted body weight is typically used]
• SCr is serum creatinine expressed in mg/dL
• IBW (male) = 50kg + 2.3 kg for each inch of height over 5 feet
• IBW (female) = 45.5kg + 2.3 kg for each inch of height over 5 feet
• Adjusted body weight = IBW + [0.4 x (actual body weight – IBW)]

The CKD-EPI equation is as follows:

• eGFR = 141 x min(SCr/κ, 1)α x max(SCr /κ, 1)-1.209 x 0.993Age x 1.018 [if female] x 1.159 [if Black]
• eGFR (estimated glomerular filtration rate) = mL/min/1.73 m2
• SCr is serum creatinine expressed in mg/dL
• κ = 0.7 (females) or 0.9 (males)
• α = -0.329 (females) or -0.411 (males)
• min = indicates the minimum of SCr/κ or 1
• max = indicates the maximum of SCr/κ or 1
• age = years. Get Health and Medical Help Today

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