Clinical Question Assignment | Homework For You
Q1 Write a focused clinical question for this particular problem that will help you organise a search of the clinical literature for an answer. [4 marks]
Q2 If you were to search Medline/PubMed/Web of science for original research on this question [8 marks] (i) Describe what your search strategy would be. Be as specific with your response, and consider specific keywords, MeSH terms, and delimiters. (ii) Explain your rationale for taking this approach and explain your reasoning. (iii) Cite the best article from among those you find, using any referencing style of your choice.
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Q3 What type of study design would best be able to address this question? Discuss why. [5 marks]
Q4 What information sources would you use to find an answer to questions such as the above? [5 marks] (i) Name at least four (4) possible types or categories of information sources as you can that could be used to find relevant evidence. (ii) Discuss at least three (3) types of information sources to demonstrate your awareness of the convenience, relevance and quality of common information sources in clinical practice.(ii) What is the risk of losing at least 5% of body weight in patients who were treated with liraglutide? [2 marks] (iii) What is the risk of losing at least 5% of body weight in patients who were treated with placebo? [2 marks] (iv) What is the relative risk of treatment with liraglutide versus placebo with regard to weight management? How would you interpret this relative risk estimate? [4 marks]
Q5b. If equal numbers of patients in the population were treated with liraglutide vs placebo treatment, what would be the expected population relative risk reduction (RRR) for liraglutide treatment? How would you interpret this measure? [4 marks] Q5c. How many patients need to be treated with liraglutide for one more patient to benefit compared with the placebo? What is this measure called? How would you interpret this measure [4 marks]
Q5d. How does the measure in question 5b differ from question 5c? [4 marks] Imagine that you have read the full report of the original research study discussed in Question 5, now answer Questions 6 to 8:
Q6. What characteristics of the study would you consider in order to determine if its findings are valid? Include wider considerations of study quality/validity and give examples. (Q8 will address relevance, and the next question will ask how to determine the importance of the findings…for this question, focus on the internal validity of the study) [16 marks]
Q7. What characteristics of the findings would you consider, in order, to determine if they are clinically meaningful and statistically significant? Include examples. (You’ve already addressed validity…for this question, focus on how to determine the clinical significance and statistical significance of an effect reported in the study) [8 marks]
Q8. What characteristics of the study would you consider, in order, to determine if it is generalizable to your context? Explain your answers and provide examples. (Questions 6 and 7 have asked how to determine if the study is valid, and how important the findings are….for this question, focus on how to determine if it is really relevant or generalizable to your practice.) Get Biology homework help today
